Propagation speeds of action potentials in the human retina compensate for traveling distances

نویسندگان

چکیده

Timing between action potentials is crucial for information processing in real neural networks. However, the physical axonal lengths largely determine time necessary to reach postsynaptic neurons. Retinal ganglion cell (RGC) axons form retinal nerve fiber layer (RNFL). The human RNFL shows a highly stereotypical organization characterized by presence of fovea, specialized region enabling high-resolution vision tasks, such as reading. To papilla (i.e., optic head), do not cross but rather some detour around it following significantly longer trajectories. We investigated whether different entail distinct conduction velocities, allowing visual signals brain synchronously. used explants precisely measure paths and propagation speeds foveal peripheral RGCs using high-density microelectrode-array recordings at subcellular resolution. Axonal were spatially heterogeneous depended on location RGC somas. Around fovea centralis, temporal traveled up 50% faster than nasal RGCs. In both retina, we observed bimodal distribution two most abundant types primate retina: midget parasol cells. Peripheral exhibited three times higher velocities axons. modelled entire predict trajectories (and thus lengths) model recapitulated well estimates strongly correlated with potential speeds. Our measurements suggest that compensatory mechanism retina contributes synchronizing arrival brain.

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ژورنال

عنوان ژورنال: Journal of Vision

سال: 2022

ISSN: ['1534-7362']

DOI: https://doi.org/10.1167/jov.22.14.3588